Guanylyl cyclase C in colorectal cancer: susceptibility gene and potential therapeutic target
نویسندگان
چکیده
منابع مشابه
Guanylyl Cyclase C Hormone Axis at the Intersection of Obesity and Colorectal Cancer.
Obesity has emerged as a principal cause of mortality worldwide, reflecting comorbidities including cancer risk, particularly in colorectum. Although this relationship is established epidemiologically, molecular mechanisms linking colorectal cancer and obesity continue to be refined. Guanylyl cyclase C (GUCY2C), a membrane-bound guanylyl cyclase expressed in intestinal epithelial cells, binds t...
متن کاملGuanylyl cyclase C signaling axis and colon cancer prevention
Colorectal cancer (CRC) is a major cause of cancer-related mortality and morbidity worldwide. While improved treatments have enhanced overall patient outcome, disease burden encompassing quality of life, cost of care, and patient survival has seen little benefit. Consequently, additional advances in CRC treatments remain important, with an emphasis on preventative measures. Guanylyl cyclase C (...
متن کاملGuanylyl cyclase: NO hits its target.
The NO receptor, NO-sensitive guanylyl cyclase, plays a key role in the NO/cGMP signal-transduction cascade. Two isoforms of the enzyme are currently known, the widely distributed vascular alpha1beta1 isoform and the neuronal alpha2beta1 isoform predominantly expressed in brain. Interaction with the PSD-95 (postsynaptic density protein-95) family of scaffolding proteins targets the neuronal alp...
متن کاملGuanylyl cyclase C messenger RNA is a biomarker for recurrent stage II colorectal cancer.
BACKGROUND Patients with stage II colorectal cancer and no histologic evidence of lymph node invasion develop recurrent disease, presumably because of undetected micrometastases. Guanylyl cyclase C is expressed by intestinal and colorectal cancer cells but not by extraintestinal tissues or tumors. OBJECTIVE To examine the expression of guanylyl cyclase C messenger RNA (mRNA) in lymph nodes of...
متن کاملExpression of the intestinal biomarkers Guanylyl cyclase C and CDX2 in poorly differentiated colorectal carcinomas.
Guanylyl cyclase C, a receptor for bacterial diarrheagenic enterotoxins, is expressed selectively by intestinal epithelium and is an endogenous downstream target of CDX2. The expression of Guanylyl cyclase C is preserved throughout the adenoma/carcinoma sequence in the colorectum. Detection of Guanylyl cyclase C expression by reverse transcriptase-polymerase chain reaction is currently being va...
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ژورنال
عنوان ژورنال: Future Oncology
سال: 2009
ISSN: 1479-6694,1744-8301
DOI: 10.2217/fon.09.14